Journal
GASTROINTESTINAL ENDOSCOPY
Volume 82, Issue 5, Pages 812-818Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.gie.2015.02.028
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Funding
- National Cancer Institute Specialized Program in Research Excellence (SPORE) Clinical Intervention Supplement [2 P50 CA62924]
- Lustgarten Foundation for Pancreatic Cancer Research
- Michael Rolfe Foundation
- Olympus Corporation
- Cooke Medical
- Karp Family H.H. & M. Metals, Inc. Fund for Cancer Research
- ChiRhoClin
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Background: Studies comparing linear and radial EUS for the detection of pancreatic lesions in an asymptomatic population with increased risk for pancreatic cancer are lacking. Objectives: To compare pancreatic lesion detection rates between radial and linear EUS and to determine the incremental diagnostic yield of a second EUS examination. Design: Randomized controlled tandem study. Setting: Five academic centers in the United States. Patients: Asymptomatic high-risk individuals (HRIs) for pancreatic cancer undergoing screening EUS. Interventions: Linear and radial EUS performed in randomized order. Main Outcome Measurements: Pancreatic lesion detection rate by type of EUS, miss rate of 1 EUS examination, and incremental diagnostic yield of a second EUS examination (second-pass effect). Results: Two hundred seventy-eight HRIs were enrolled, mean age 56 years (43.2%), and 90% were familial pancreatic cancer relatives. Two hundred twenty-four HRIs underwent tandem radial and linear EUS. When we used per-patient analysis, the overall prevalence of any pancreatic lesion was 45%. Overall, 16 of 224 HRIs (7.1%) had lesions missed during the initial EUS that were detected by the second EUS examination. The per-patient lesion miss rate was significantly greater for radial followed by linear EUS (9.8%) than for linear followed by radial EUS (4.5%) (P = .03). When we used per-lesion analysis, 73 of 109 lesions (67%) were detected by radial EUS and 99 of 120 lesions (82%) were detected by linear EUS (P < .001) during the first examination. The overall miss rate for a pancreatic lesion after 1 EUS examination was 47 of 229 (25%). The miss rate was significantly lower for linear EUS compared with radial EUS (17.5% vs 33.0%, P = .007). Limitations: Most detected pancreatic lesions were not confirmed by pathology. Conclusion: Linear EUS detects more pancreatic lesions than radial EUS. There was a second-pass effect with additional lesions detected with a second EUS examination. This effect was significantly greater when linear EUS was used after an initial radial EUS examination.
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