4.7 Article

A New Ratiometric Lysosomal Copper(II) Fluorescent Probe To Map a Dynamic Metallome in Live Cells

Journal

INORGANIC CHEMISTRY
Volume 57, Issue 5, Pages 2365-2368

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.inorgchem.7b02720

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We synthesized a new ratiometric fluorescent Cu2+ probe, bearing a morpholine moiety for selective binding to lysosomes and two picolylamine arms for the specific chelation of divalent copper ions. The probe capability to detect lysosomal Cu2+ was demonstrated in human differentiated neuroblastoma cells by confocal microscopy.

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