Journal
INFLAMMATORY BOWEL DISEASES
Volume 25, Issue 1, Pages 56-66Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/ibd/izy208
Keywords
acute severe ulcerative colitis; salvage therapy; infliximab; medical management
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Funding
- National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health [T32DK007727, K23DK09483]
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Acute severe ulcerative colitis is a medical emergency that requires prompt recognition, evaluation, and intervention. Patients require hospital admission with laboratory, radiographic, and endoscopic evaluation with initiation of corticosteroid treatment. Despite early intervention, many patients require salvage medical therapy, with some progressing to colectomy. Here we review important concepts and recent advances in the evaluation and medical management of adult and pediatric patients with acute severe ulcerative colitis.
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