Journal
IMMUNOLOGY LETTERS
Volume 197, Issue -, Pages 70-77Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.imlet.2018.03.006
Keywords
Live bacterial vaccine vector; Attenuated bacteria; Probiotic; Bacterial surface display system; Bacterial secretion system; Balanced lethal vector system
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Funding
- Natural Science Foundation of China [31371776]
- Agricultural Science Promotion Plan of Shanghai [4-4]
- Science and Technology Innovation Plan of Shanghai: Yangtze River Delta Joint Research [15395810900]
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Live bacteria, including attenuated bacteria and probiotics, can be engineered to deliver target antigen to excite the host immune system. The preponderance of these live bacterial vaccine vectors is that they can stimulate durable humoral and cellular immunity. Moreover, delivery strategies of heterologous antigen in live bacterial promote the applications of new vaccine development. Genetic technologies are evolving, which potentiate the developing of heterologous antigen delivery systems, including bacterial surface display system, bacterial secretion system and balanced lethal vector system. Although the live bacterial vaccine vector is a powerful adjuvant, certain disadvantages, such as safety risk, must also be taken into account. In this review, we compare the development of representative live bacterial vectors, and summarize the main characterizations of the various delivery strategies of heterologous antigen in live vector vaccines.
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