Journal
IMMUNOLOGY AND CELL BIOLOGY
Volume 96, Issue 5, Pages 477-484Publisher
WILEY
DOI: 10.1111/imcb.12045
Keywords
Cancer; IL-15; immune homeostasis; Interleukins; NK cells; STAT5
Categories
Funding
- National Health and Medical Research Council (NHMRC) of Australia [1049407, 1066770, 1057852, 1027472]
- NHMRC CDF2 fellowship
- NHMRC Independent Research Institute Infrastructure Support scheme grant
- Victorian State Government Operational Infrastructure Scheme grant
- Ian Potter Foundation (AUS)
- Tour De Cure (AUS)
- Harry J Lloyd Charitable Trust (USA)
- Melanoma Research Alliance (USA)
- Cancer Research Institute (USA)
- National Health and Medical Research Council of Australia [1066770] Funding Source: NHMRC
- National Breast Cancer Foundation [PF-15-008] Funding Source: researchfish
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Natural Killer (NK) cells have long been considered an important part of the anti-tumor immune response due to their potent cytolytic and cytokine-secreting abilities. To date, a clear demonstration of the role NK cells play in human cancer is lacking, and there are still very few examples of therapies that efficiently exploit or enhance the spontaneous ability of NK cells to destroy the autologous cancer cells. Given the paradigm shift toward cancer immunotherapy over the past decade, there is a renewed push to understand how NK cell homeostasis and function are regulated in order to therapeutically harness these cells to treat cancer. This review will highlight recent advancements in our understanding of how growth factors impact on NK cell development, differentiation, survival and function with an emphasis on how these pathways may influence NK cell activity in the tumor microenvironment and control of cancer metastasis.
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