Journal
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA
Volume 38, Issue 3, Pages 443-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.iac.2018.04.013
Keywords
Mastocytosis; Osteoporosis; Osteosclerosis; Fracture; Bone mineral density; Bone turnover markers
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Systemic mastocytosis can give very different bone pictures: from osteosclerosis to osteoporosis. Osteoporosis is one of the most frequent manifestations particularly in adults and the most clinically relevant. It is often complicated by a high recurrence of mainly vertebral fragility fractures. The main factor of bone loss is the osteoclast with a relative or absolute predominance of bone resorption. The RANK-RANKL pathway seems of key importance, but histamine and other cytokines also play a significant role in the process. The predominance of resorption made bisphosphonates, as antiresorptive drugs, the most rational treatment of bone involvement in systemic mastocytosis.
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