Journal
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA
Volume 38, Issue 3, Pages 341-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.iac.2018.04.014
Keywords
Mastocytosis; Mast cell; Clonal mast cell disorders; Monoclonal mast cell activation syndrome; Mast cell sarcoma; Tryptase; Mast cell leukemia
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Mastocytosis is a heterogeneous group of neoplasms that involve the clonal expansion of mast cells into one or more organ systems, which typically involves the skin and hematopoietic systems. Systemic mastocytosis consists of a multifocal infiltration of mast cells into various noncutaneous tissue sites, especially the bone marrow. Diagnosis requires tissue confirmation, and algorithms have been developed to assist clinicians in this process. The current classification system focuses on delineating prognostic categories. Therapeutic approaches include symptomatic management, prevention of complications, and, in advanced disease, cytoreductive therapy.
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