Related references
Note: Only part of the references are listed.Hypoxic stress: obstacles and opportunities for innovative immunotherapy of cancer
S. Chouaib et al.
ONCOGENE (2017)
Metabolic Instruction of Immunity
Michael D. Buck et al.
CELL (2017)
Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy
Shari Pilon-Thomas et al.
CANCER RESEARCH (2016)
Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF- and miR23a transfer
Guy Berchem et al.
ONCOIMMUNOLOGY (2016)
Inhibition of HIF-1α enhances anti-tumor effects of dendritic cell-based vaccination in a mouse model of breast cancer
Nasim Kheshtchin et al.
CANCER IMMUNOLOGY IMMUNOTHERAPY (2016)
CRLX101, an investigational nanoparticle-drug conjugate of camptothecin, demonstrates synergy with immunotherapy agents in preclinical models
Douglas Lazarus et al.
CANCER RESEARCH (2016)
Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer
Caroline Wigerup et al.
PHARMACOLOGY & THERAPEUTICS (2016)
The multifaceted role of autophagy in tumor evasion from immune surveillance
Bassam Janji et al.
ONCOTARGET (2016)
Overcoming Hypoxia-Mediated Tumor Progression:Combinatorial Approaches Targeting pH Regulation,Angiogenesis and Immune Dysfunction
Paul C. McDonald et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2016)
Hypoxia: a key player in antitumor immune response. A Review in the Theme: Cellular Responses to Hypoxia
Muhammad Zaeem Noman et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2015)
Macrophages: Development and Tissue Specialization
Chen Varol et al.
ANNUAL REVIEW OF IMMUNOLOGY VOL 33 (2015)
Production and Characterization of a Came lid Single Domain Antibody-Urease Enzyme Conjugate for the Treatment of Cancer
Baomin Tian et al.
BIOCONJUGATE CHEMISTRY (2015)
Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Absence of p53 Function
N. V. Rajeshkumar et al.
CANCER RESEARCH (2015)
The Selective Degradation of Synaptic Connexin 43 Protein by Hypoxia-induced Autophagy Impairs Natural Killer Cell-mediated Tumor Cell Killing
Andres Tittarelli et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Immune Response Regulation in the Tumor Microenvironment by Hypoxia
Sara Labiano et al.
SEMINARS IN ONCOLOGY (2015)
Chronic acidosis in the tumour microenvironment selects for overexpression of LAMP2 in the plasma membrane
Mehdi Damaghi et al.
NATURE COMMUNICATIONS (2015)
Tumor hypoxia drives immune suppression and immunotherapy resistance
Midan Ai et al.
Journal for ImmunoTherapy of Cancer (2015)
Autophagic degradation of GZMB/granzyme B
Elodie Viry et al.
AUTOPHAGY (2014)
PD-L1 is a novel direct target of HIF-1α., and its blockade under hypoxia enhanced MDSC-mediated T cell activation
Muhammad Zaeem Noman et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2014)
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
Oscar R. Colegio et al.
NATURE (2014)
Myeloid-Derived Suppressor Cells in Cancer: Therapeutic, Predictive, and Prognostic Implications
C. Marcelo Diaz-Montero et al.
SEMINARS IN ONCOLOGY (2014)
Molecular mechanisms that influence the macrophage M1-M2 polarization balance
Nan Wang et al.
FRONTIERS IN IMMUNOLOGY (2014)
Separation of metabolic supply and demand: aerobic glycolysis as a normal physiological response to fluctuating energetic demands in the membrane
Tamir Epstein et al.
CANCER & METABOLISM (2014)
Altered energy metabolism in cancer A unique opportunity for therapeutic intervention
Yi Zhang et al.
CANCER BIOLOGY & THERAPY (2013)
Evaluation of LDH-A and Glutaminase Inhibition In Vivo by Hyperpolarized 13C-Pyruvate Magnetic Resonance Spectroscopy of Tumors
Prasanta Dutta et al.
CANCER RESEARCH (2013)
The Emerging Hallmarks of Metabolic Reprogramming and Immune Evasion: Distinct or Linked?
Irina Kareva et al.
CANCER RESEARCH (2013)
Activity of the Hypoxia-Activated Prodrug, TH-302, in Preclinical Human Acute Myeloid Leukemia Models
Scott Portwood et al.
CLINICAL CANCER RESEARCH (2013)
Targeting lactate metabolism for cancer therapeutics
Joanne R. Doherty et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Cutting Edge: Hypoxia-Induced Nanog Favors the Intratumoral Infiltration of Regulatory T Cells and Macrophages via Direct Regulation of TGF- β1
Meriem Hasmim et al.
JOURNAL OF IMMUNOLOGY (2013)
Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells
Zaheed Husain et al.
JOURNAL OF IMMUNOLOGY (2013)
Granzyme B degradation by autophagy decreases tumor cell susceptibility to natural killer-mediated lysis under hypoxia
Joanna Baginska et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
Douglas Hanahan et al.
CANCER CELL (2012)
Primary Tumor Hypoxia Recruits CD11b+/Ly6Cmed/Ly6G+ Immune Suppressor Cells and Compromises NK Cell Cytotoxicity in the Premetastatic Niche
Jaclyn Sceneay et al.
CANCER RESEARCH (2012)
Modulation of Microenvironment Acidity Reverses Anergy in Human and Murine Tumor-Infiltrating T Lymphocytes
Arianna Calcinotto et al.
CANCER RESEARCH (2012)
Molecular Pathways: Hypoxia Response in Immune Cells Fighting or Promoting Cancer
Asis Palazon et al.
CLINICAL CANCER RESEARCH (2012)
Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity
Suzanne L. Topalian et al.
CURRENT OPINION IN IMMUNOLOGY (2012)
Macrophage plasticity and polarization: in vivo veritas
Antonio Sica et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Systemic Buffers Inhibit Carcinogenesis in TRAMP Mice
Arig Ibrahim-Hashim et al.
JOURNAL OF UROLOGY (2012)
Immunology beats cancer: a blueprint for successful translation
Drew M. Pardoll
NATURE IMMUNOLOGY (2012)
Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa
Eric T. Clambey et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Tumor-Recruited Neutrophils and Neutrophil TIMP-Free MMP-9 Regulate Coordinately the Levels of Tumor Angiogenesis and Efficiency of Malignant Cell Intravasation
Erin M. Bekes et al.
AMERICAN JOURNAL OF PATHOLOGY (2011)
Hypoxia Induces Escape from Innate Immunity in Cancer Cells via Increased Expression of ADAM10: Role of Nitric Oxide
Ivraym B. Barsoum et al.
CANCER RESEARCH (2011)
Lactate: A Metabolic Key Player in Cancer
Franziska Hirschhaeuser et al.
CANCER RESEARCH (2011)
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
Eric V. Dang et al.
CELL (2011)
From Tumor Immunosuppression to Eradication: Targeting Homing and Activity of Immune Effector Cells to Tumors
Oana Draghiciu et al.
CLINICAL & DEVELOPMENTAL IMMUNOLOGY (2011)
Reduction of metastasis using a non-volatile buffer
Arig Ibrahim Hashim et al.
CLINICAL & EXPERIMENTAL METASTASIS (2011)
Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia
Aude Carreau et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2011)
Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice
Sarah R. Walmsley et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
The Role of Tumor-Infiltrating Immune Cells and Chronic Inflammation at the Tumor Site on Cancer Development, Progression, and Prognosis Emphasis on Non-small Cell Lung Cancer
Roy M. Bremnes et al.
JOURNAL OF THORACIC ONCOLOGY (2011)
Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells
Andrea Facciabene et al.
NATURE (2011)
In vivo T cell activation in lymphoid tissues is inhibited in the oxygen-poor microenvironment
Akio Ohta et al.
FRONTIERS IN IMMUNOLOGY (2011)
Targeting the multiple myeloma hypoxic niche with TH-302, a hypoxia-activated prodrug
Jinsong Hu et al.
BLOOD (2010)
Macrophage Expression of Hypoxia-Inducible Factor-1α Suppresses T-Cell Function and Promotes Tumor Progression
Andrew L. Doedens et al.
CANCER RESEARCH (2010)
Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes
Kiavash Movahedi et al.
CANCER RESEARCH (2010)
Macrophage Diversity Enhances Tumor Progression and Metastasis
Bin-Zhi Qian et al.
CELL (2010)
Differential activation and antagonistic function of HIF-α isoforms in macrophages are essential for NO homeostasis
Norihiko Takeda et al.
GENES & DEVELOPMENT (2010)
Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation
Juan-Carlos Rodriguez-Prados et al.
JOURNAL OF IMMUNOLOGY (2010)
Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia
Hsin-Yu Fang et al.
BLOOD (2009)
Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases
Ian F. Robey et al.
CANCER RESEARCH (2009)
Hypoxia skews dendritic cells to a T helper type 2-stimulating phenotype and promotes tumour cell migration by dendritic cell-derived osteopontin
Meixiang Yang et al.
IMMUNOLOGY (2009)
Restoring the association of the T cell receptor with CD8 reverses anergy in human tumor-infiltrating lymphocytes
Nathalie Demotte et al.
IMMUNITY (2008)
Hypoxia and hypoxia-inducible factor-1α modulate lipopolysaccharide-induced dendritic cell activation and function
Jonathan Jantsch et al.
JOURNAL OF IMMUNOLOGY (2008)
Causes and consequences of increased glucose metabolism of cancers
Robert J. Gillies et al.
JOURNAL OF NUCLEAR MEDICINE (2008)
How regulatory T cells work
Dario A. A. Vignali et al.
NATURE REVIEWS IMMUNOLOGY (2008)
Targeted Deletion of HIF-1α Gene in T Cells Prevents their Inhibition in Hypoxic Inflamed Tissues and Improves Septic Mice Survival
Manfred Thiel et al.
PLOS ONE (2007)
Tumor microenvironment: The role of the tumor stroma in cancer
Hanchen Li et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2007)
Importance of culturing primary lymphocytes at physiological oxygen levels
Kondala R. Atkuri et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Macrophages regulate the angiogenic switch in a mouse model of breast cancer
Elaine Y. Lin et al.
CANCER RESEARCH (2006)
A2A adenosine receptor protects tumors from antitumor T cells
Akio Ohta et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma
I Kryczek et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2006)
Extracellular acidosis induces neutrophil activation by a mechanism dependent on activation of phosphatidylinositol 3-kinase/Akt and ERK pathways
D Martínez et al.
JOURNAL OF IMMUNOLOGY (2006)
Macrophage migration and gene expression in response to tumor hypoxia
C Murdoch et al.
INTERNATIONAL JOURNAL OF CANCER (2005)
Hypoxia inducible factor 1α regulates T cell receptor signal transduction
AK Neumann et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Tie2 identifies a hematopoietic monocytes required for tumor lineage of proangiogenic vessel formation and a mesenchymal population of pericyte progenitors
M De Palma et al.
CANCER CELL (2005)
HIF-1α expression regulates the bactericidal capacity of phagocytes
C Peyssonnaux et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
Culturing at atmospheric oxygen levels impacts lymphocyte function
KR Atkuri et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
RK Jain
SCIENCE (2005)
Hypoxia-induced neutrophil survival is mediated by HIF-1α-dependent NF-κB activity
SR Walmsley et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2005)
Macrophage responses to hypoxia - Implications for tumor progression and anti-cancer therapies
C Lewis et al.
AMERICAN JOURNAL OF PATHOLOGY (2005)
Acidosis improves uptake of antigens and MHC class I-restricted presentation by dendritic cells
M Vermeulen et al.
JOURNAL OF IMMUNOLOGY (2004)
Hypoxic gene activation by lipopolysaccharide in macrophages:: Implication of hypoxia-inducible factor 1α
CC Blouin et al.
BLOOD (2004)
Why do cancers have high aerobic glycolysis?
RA Gatenby et al.
NATURE REVIEWS CANCER (2004)
Arginine availability, arginase, and the immune response
V Bansal et al.
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2003)
Differential effects of physiologically relevant hypoxic conditions on T lymphocyte development and effector functions
CC Caldwell et al.
JOURNAL OF IMMUNOLOGY (2001)
Share Paper
