Journal
IMMUNOLOGICAL REVIEWS
Volume 283, Issue 1, Pages 99-112Publisher
WILEY
DOI: 10.1111/imr.12653
Keywords
adenovirus; CD8(+) T cell; cytomegalovirus; exhaustion; inflation; memory; vaccination
Categories
Funding
- National Institute for Health Research (Biomedical Research Centre, Oxford)
- National Institutes of Health [U19 AI082630]
- Wellcome Trust [WT109965MA65]
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Memory inflation, as a term, has been used for 15years now to describe the longitudinal development of stable, expanded CD8(+) T memory pools with a distinct phenotype and functional profile which emerge in specific infection and vaccine settings. These settings have in common the persistence of antigen, especially cytomegalovirus infection but also more recently adenoviral vector vaccination. However, in contrast to chronic infections which lead to exhaustion the repeated antigen encounters experienced by CD8(+) T cells lead to development of a robust T-cell population structure which maintains functionality and size. In this review, I will discuss how the ideas around this form of memory have evolved over time and some new models which can help explain how these populations are induced and sustained. These models are relevant to immunity against persistent viruses, to novel vaccine strategies and to concepts about aging.
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