Journal
IMMUNOLOGICAL REVIEWS
Volume 282, Issue 1, Pages 151-167Publisher
WILEY
DOI: 10.1111/imr.12638
Keywords
cytokines; eosinophils; homeostasis; inflammation; lineage; mast cells; mediators; receptors
Categories
Funding
- Israel Science Foundation [472/15]
- U.S. Department of Health and Human Services, National Institutes of Health, National Heart, Lung, and Blood Institute [P01 HL107151]
- U.S. Department of Health and Human Services, National Institutes of Health, National Institute of Allergy and Infectious Diseases [R01 AI072265, R01 AI105839, T32 AI083216]
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While the origin of the phrase birds of a feather flock together is unclear, it has been in use for centuries and is typically employed to describe the phenomenon that people with similar tastes or interests tend to seek each other out and congregate together. In this review, we have co-opted this phrase to compare innate immune cells of related origin, the eosinophil and mast cell, because they very often accumulate together in tissue sites under both homeostatic and inflammatory conditions. To highlight overlapping yet distinct features, their hematopoietic development, cell surface phenotype, mediator release profiles and roles in diseases have been compared and contrasted. What emerges is a sense that these two cell types often interact with each other and their tissue environment to provide synergistic contributions to a variety of normal and pathologic immune responses.
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