Journal
IMMUNITY
Volume 48, Issue 6, Pages 1135-+Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2018.04.019
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Funding
- US National Institutes of Health [R37 AI027998, R01 AI039614]
- Intramural Research Program of the National Institutes of Health, National Institute on Aging
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI027998, R37AI027998, R01AI039614] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [ZIAAG000732] Funding Source: NIH RePORTER
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Although immune memory often lasts for life, this is not the case for certain vaccines in some individuals. We sought a mechanism for this phenomenon by studying B cell responses to phycoerythrin (PE). PE immunization of mouse strains with Igh(b) immunoglobulin (Ig) variable heavy chain (V-H) genes elicited affinity-matured switched Ig memory B cells that declined with time, while the comparable population from an Igh(a) strain was numerically stable. Igh(b) strains had larger numbers of PE-specific naive B cells and generated smaller germinal center responses and larger numbers of IgM memory cells than the Igh(a) strain. The properties of PE-specific B cells in Igh(b) mice correlated with usage of a single V-H that afforded high-affinity PE binding in its germline form. These results suggest that some individuals may be genetically predisposed to generate non-canonical memory B cell responses to certain antigens because of avid antigen binding via germline-encoded V-H elements.
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