Journal
IMMUNITY
Volume 48, Issue 5, Pages 1006-+Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2018.04.020
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Funding
- NIH/NIGMS grant [R01GM099970]
- American Asthma Foundation Scholar award
- MSKCC Functional Genome Initiative
- NIH/NCI Cancer Center Support grant [P30CA008748]
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Tissue damage and infection are deemed likewise triggers of innate immune responses. But whereas neutrophil responses to microbes are generally protective, neutrophil recruitment into damaged tissues without infection is deleterious. Why neutrophils respond to tissue damage and not just to microbes is unknown. Is it a flaw of the innate immune system that persists because evolution did not select against it, or does it provide a selective advantage? Here we dissect the contribution of tissue damage signaling to antimicrobial immune responses in a live vertebrate. By intravital imaging of zebrafish larvae, a powerful model for innate immunity, we show that prevention of tissue damage signaling upon microbial ear infection abrogates leukocyte chemotaxis and reduces animal survival, at least in part, through suppression of cytosolic phospholipase A(2) (cPla(2)), which integrates tissue damage- and microbederived cues. Thus, microbial cues are insufficient, and damage signaling is essential for antimicrobial neutrophil responses in zebrafish.
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