Journal
CRITICAL CARE
Volume 18, Issue 6, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/s13054-014-0508-y
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Funding
- Shanghai Leading Academic Discipline Project [B115]
- Zhongshan Distinguished Professor Grant
- National Nature Science Foundation of China [91230204, 81270099, 81320108001, 81270131, 81300010]
- Shanghai Committee of Science and Technology [12JC1402200, 12431900207, 11410708600]
- Zhejiang Provincial Natural Science Foundation [Z2080988]
- Zhejiang Provincial Science Technology Department Foundation [2010C14011]
- Ministry of Education, Academic Special Science and Research Foundation for PhD Education [20130071110043]
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Introduction: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a serious event that is responsible for the progress of the disease, increases in medical costs and high mortality. Methods: The aim of the present study was to identify AECOPD-specific biomarkers by evaluating the dynamic gene expression profiling of peripheral blood mononuclear cells (PBMCs) from patients with AECOPD on days 1, 3 and 10 after hospital admission and to compare the derived data with data from healthy controls or patients with stable COPD. Results: We found that 14 genes were co-differentially upregulated and 2 downregulated greater than 10-fold in patients with COPD or AECOPD compared with the healthy individuals. Eight co-differentially upregulated genes and six downregulated genes were identified as a panel of AECOPD-specific genes. Downregulation of TCF7 in PBMCs was found to be associated with the severity of COPD. Dynamic changes of Aminolevulinate-delta-synthase 2 and carbonic anhydrase I had similar patterns of Digital Evaluation Score System scores and may serve as potential genes of interest during the course of AECOPD. Conclusion: Thus, our findings indicate a panel of altered gene expression patterns in PBMCs that can be used as AECOPD-specific dynamic biomarkers to monitor the course of AECOPD.
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