Journal
IET NANOBIOTECHNOLOGY
Volume 12, Issue 2, Pages 191-195Publisher
INST ENGINEERING TECHNOLOGY-IET
DOI: 10.1049/iet-nbt.2016.0221
Keywords
organic compounds; graphene devices; quantum dots; enzymes; biosensors; biochemistry; electrochemical electrodes; electrochemical sensors; transmission electron microscopy; scanning electron microscopy; voltammetry (chemical analysis); electrochemical impedance spectroscopy; nanomedicine; molecular biophysics; sensitive uric acid determination; graphene quantum dots; uric oxidase immobilisation; electrochemical detection; GQD; enzyme immobilisation; glassy carbon electrode; GCE; transmission electron microscope; scanning electron microscopy; cyclic voltammetry; electrochemical impedance spectroscopy; electrochemical biosensor; C
Funding
- National Natural Science Foundation of China [81573200, 81373047, 81773480]
- Foundation of outstanding leaders training program of Pudong Health Bureau of Shanghai [PWRI2016-04]
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A novel strategy for highly sensitive electrochemical detection of uric acid (UA) was proposed based on graphene quantum dots (GQDs), GQDs were introduced as a suitable substrate for enzyme immobilisation. Uric oxidase (UOx) was immobilised on GQDs modified glassy carbon electrode (GCE). Transmission electron microscope, scanning electron microscopy, cyclic voltammetry and electrochemical impedance spectroscopy techniques were used for characterising the electrochemical biosensor. The developed biosensor responds efficiently to UA presence over the concentration linear range 1-800M with the detection limit 0.3M. This novel biosensing platform based on UOx/GQDs electrode responded even more sensitively than that based on GCE modified by UOx alone. The inexpensive, reliable and sensitive sensing platform based on UOx/GQDs electrode provides wide potential applications in clinical.
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