Journal
GASTROENTEROLOGY CLINICS OF NORTH AMERICA
Volume 44, Issue 1, Pages 21-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.gtc.2014.11.003
Keywords
Gastroparesis; Pathophysiology 0; Gastric motor function; Gastric emptying; Visceral hypersensitivity; Gastric accommodation
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Gastroparesis is a heterogeneous disorder defined by delay in gastric emptying. Symptoms of gastroparesis are nonspecific, including nausea, vomiting, early satiety, bloating, and/or abdominal pain. Normal gastric motor function and sensory function depend on a complex coordination between the enteric and central nervous system. This article discusses the pathophysiology of delayed gastric emptying and the symptoms of gastroparesis, including antropyloroduodenal dysmotility, impaired gastric accommodation, visceral hypersensitivity, and autonomic dysfunction. The underlying pathophysiology of gastroparesis is complex and multifactorial.The article discusses how a combination of these factors leads to symptoms of gastroparesis.
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