Journal
VETERINARY INFECTION BIOLOGY: MOLECULAR DIAGNOSTICS AND HIGH-THROUGHPUT STRATEGIES
Volume 1247, Issue -, Pages 437-474Publisher
HUMANA PRESS INC
DOI: 10.1007/978-1-4939-2004-4_31
Keywords
Parasitic nematodes; Genomics; Transcriptomics; Bioinformatics; Next-generation sequencing; Post-genomics; Anthelmintic resistance; Drug targets; Diagnostic markers
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High-throughput molecular and computer technologies have become instrumental for systems biological explorations of pathogens, including parasites. For instance, investigations of the transcriptomes of different developmental stages of parasitic nematodes give insights into gene expression, regulation and function in a parasite, which is a significant step to understanding their biology, as well as interactions with their host(s) and disease. This chapter (1) gives a background on some key parasitic nematodes of socioeconomic importance, (2) describes sequencing and bioinformatic technologies for large-scale studies of the transcriptomes and genomes of these parasites, (3) provides some recent examples of applications and (4) emphasizes the prospects of fundamental biological explorations of parasites using these technologies for the development of new interventions to combat parasitic diseases.
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