Journal
TOXICOLOGY REPORTS
Volume 2, Issue -, Pages 737-747Publisher
ELSEVIER
DOI: 10.1016/j.toxrep.2015.05.007
Keywords
Aflatoxin B-1; Chitosan nanoparticles; Quercetin; Genotoxicity; Liver; Gene expression
Categories
Funding
- National Research Center (Dokki, Cairo, Egypt) [10070112]
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The aims of the current study were to prepare chitosan nanoparticles (CNPs) and to evaluate its protective role alone or in combination with quercetin (Q) against AFB(1)-induce cytotoxicity in rats. Male Sprague-Dawley rats were divided into 12 groups and treated orally for 4 weeks as follow: the control group, the group treated with AFB(1) (80 mu g/kg b.w.) in corn oil, the groups treated with low (140 mg/kg b.w.) or high (280 mg/kg b.w) dose of CNPs, the group treated with Q (50 mg/kg b.w.), the groups treated with Q plus the low or the high dose of CNPs and the groups treated with AFB(1) plus Q and/or CNPs at the two tested doses. The results also revealed that administration of AFB(1) resulted in a significant increase in serum cytokines, Procollagen III, Nitric Oxide, lipid peroxidation and DNA fragmentation accompanied with a significant decrease in GPx I and Cu-Zn SOD-mRNA gene expression. Q and/or CNPs at the two tested doses overcome these effects especially in the group treated with the high dose of CNPs plus Q. It could be concluded that CNPs is a promise candidate as drug delivery enhances the protective effect of Q against the cytogenetic effects of AFB(1) in high endemic areas. (C) 2015 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license.
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