3.8 Review

Drosophila as a Potential Model for Ocular Tumors

Journal

OCULAR ONCOLOGY AND PATHOLOGY
Volume 1, Issue 3, Pages 190-199

Publisher

KARGER
DOI: 10.1159/000370155

Keywords

Ocular oncology; Retinoblastoma; Uveal melanoma; Drosophila; Cancer model; Ocular cancer

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Funding

  1. CRUK
  2. NWCR
  3. National Institute for Health Research [ACF-2014-06-002] Funding Source: researchfish

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Drosophila has made many contributions to our understanding of cancer genes and mechanisms that have subsequently been validated in mammals. Despite anatomical differences between fly and human eyes, flies offer a tractable genetic model in which to dissect the functional importance of genetic lesions found to be affected in human ocular tumors. Here, we discuss different approaches for using Drosophila as a model for ocular cancer and how studies on ocular cancer genes in flies have begun to reveal potential strategies for therapeutic intervention. We also discuss recent developments in the use of Drosophila for drug discovery, which is coming to the fore as Drosophila models are becoming tailored to study tumor types found in the clinic. (C) 2015 S. Karger AG, Basel

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