Journal
MOLECULAR & CELLULAR ONCOLOGY
Volume 2, Issue 3, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/23723556.2014.995047
Keywords
cell death; lipid peroxidation; non-apoptotic cell death; regulated necrosis
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The system X-C(-)/glutathione/glutathione peroxidase 4 (Gpx4) axis pivotally controls ferroptosis, a recently described form of regulated non-apoptotic cell death. Compelling evidence has established that this route of cell death is not only of high relevance for triggering cancer cell death, but also proves to be amenable for therapeutic intervention to halt ischemia/reperfusion-related diseases.
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