Journal
MOLECULAR & CELLULAR ONCOLOGY
Volume 2, Issue 4, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/23723556.2014.1002712
Keywords
renal cancer; autophagy; VHL; microRNA
Categories
Funding
- NCI [CA122346]
- BLR&D VA Merit Award
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In clear cell renal cell carcinoma (ccRCC), oncogenic autophagy dependent on microtubule-associated protein 1 light chain 3 a and beta (LC3A and LC3B) is stimulated by activity of the transient receptor potential melastatin 3 (TRPM3) channel through multiple complementary mechanisms. The Von Hippel-Lindau (VHL) tumor suppressor represses this oncogenic autophagy in a coordinated manner through the activity of miR-204, which is expressed from intron 6 of the gene encoding TRPM3. TRPM3 represents an actionable target for ccRCC treatment.
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