Journal
MOLECULAR & CELLULAR ONCOLOGY
Volume 2, Issue 2, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/23723556.2014.976491
Keywords
aneuploidy; cancer; HSF1; HSP90; proteotoxic stress
Categories
Funding
- Max Planck Society
- Center for Integrated Protein Science, Munich
- Deutsche Forschungsgemeinschaft
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Although nearly ubiquitous in cancer, aneuploidy exerts detrimental effects on human cells. We recently demonstrated that aneuploid human cells exhibit impaired heat shock factor protein 1 (HSF1) and HSP90 function, suggesting a functional link between two recurring features of cancer cells: aneuploidy and proteotoxic stress. Further, our findings implicate HSF1 as a key factor in mitigating the effects of aneuploidy.
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