Journal
NEUROBIOLOGY OF STRESS
Volume 1, Issue -, Pages 33-43Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ynstr.2014.09.007
Keywords
Neuropeptide Y; Stress resilience; Stress-related psychiatric disorders; Rodent models; Emotionality
Categories
Funding
- National Institutes of Health [DA09082]
- US Army, Department of Defense Medical Research and Development Program [DM102281]
- CDMRP [545735, DM102281] Funding Source: Federal RePORTER
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Repeated, extreme, or traumatic stressors can elicit pathological effects leading to many negative physical and psychological outcomes. Stressors can precipitate the onset of psychiatric diseases, or exacerbate pre-existing disorders including various anxiety and mood disorders. As stressors can negatively impact human psychiatric health, it is essential to identify neurochemicals that may confer protection from the negative sequelae of repeated or extreme stress exposure. Elucidating the neurobiological underpinnings of stress resilience will enhance our ability to promote resilience to, or recovery from, stress-related psychiatric disease. Herein, we will review the evidence for neuropeptide Y as an endogenous mediator of resilience and its potential relevance for the treatment of stress-related psychiatric diseases. (C) 2014 The Authors. Published by Elsevier Inc.
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