Journal
RSC ADVANCES
Volume 5, Issue 6, Pages 4592-4598Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ra14478c
Keywords
-
Categories
Funding
- Council of Scientific and Industrial Research (CSIR), New Delhi
- Department of Science and Technology (DST)-SERB, India [SR/S1/OC-09-2012]
Ask authors/readers for more resources
The present work reports a highly efficient and biocatalytic heterogeneous protocol for kinetic resolution (KR) of racemic secondary alcohols with vinyl acetate as an acyl donor, using the biocatalyst Burkholderia cepacia lipase (BCL) immobilized on a biodegradable ternary blend support through polylactic acid (PLA)/polyvinyl alcohol (PVA)/chitosan (CHI); (PLA/PVA/CHI-BCL). The KR reaction with various substituted aromatic, heterocyclic racemic secondary alcohols gave enantiomerically pure alcohol and its enantioenriched acetate derivatives with high conversion (45-50%) and excellent enantiomeric excess (up to 99% ee) at optimized reaction conditions. The reaction works under mild conditions using simple and inexpensive starting materials such as racemic alcohols, vinyl acetate, and immobilized biocatalyst. The given protocol provides excellent recyclability with good yield and enantiomeric excess values up to the studied range of five cycles. The resultant products were characterized with the help of different analytical techniques such as H-1 and C-13-NMR, chiral HPLC column, polarimeter, IR and GC-MS.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available