Journal
NATURE REVIEWS IMMUNOLOGY
Volume 15, Issue 2, Pages 73-86Publisher
NATURE PORTFOLIO
DOI: 10.1038/nri3789
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Funding
- US National Institutes of Health [RO1 CA172451, PO1CA100324]
- Wellcome Trust, UK [SIA 101067/Z/13/Z]
- Cancer Research UK [17367] Funding Source: researchfish
- Medical Research Council [G1002033] Funding Source: researchfish
- Wellcome Trust [101067/Z/13/Z] Funding Source: researchfish
- MRC [G1002033] Funding Source: UKRI
- Wellcome Trust [101067/Z/13/Z] Funding Source: Wellcome Trust
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Metastatic disease is the major cause of death from cancer, and immunotherapy and chemotherapy have had limited success in reversing its progression. Data from mouse models suggest that the recruitment of immunosuppressive cells to tumours protects metastatic cancer cells from surveillance by killer cells, which nullifies the effects of immunotherapy and thus establishes metastasis. Furthermore, in most cases, tumour-infiltrating immune cells differentiate into cells that promote each step of the metastatic cascade and thus are novel targets for therapy. In this Review, we describe how tumour-infiltrating immune cells contribute to the metastatic cascade and we discuss potential therapeutic strategies to target these cells.
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