Journal
EMERGING INFECTIOUS DISEASES
Volume 21, Issue 2, Pages 242-250Publisher
CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid2101.140795
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Funding
- Bill and Melinda Gates Foundation [BMGF 38874, BMGF OPP42917, BMGF OPP1016839]
- National Institutes of Health [U19 090873]
- US National Science Foundation [DGE0750616]
- Medical Research Council [MC_U190074190, MC_U190081991] Funding Source: researchfish
- MRC [MC_U190081991, MC_U190074190] Funding Source: UKRI
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Pathogens in the gastrointestinal tract exist within a vast population of microbes. We examined associations between pathogens and composition of gut microbiota as they relate to Shigella spp./enteroinvasive Escherichia coli infection. We analyzed 3,035 stool specimens (1,735 nondiarrheal and 1,300 moderate-to-severe diarrheal) from the Global Enteric Multicenter Study for 9 enteropathogens. Diarrheal specimens had a higher number of enteropathogens (diarrheal mean 1.4, nondiarrheal mean 0.95; p<0.0001). Rotavirus showed a negative association with Shigella spp. in cases of diarrhea (odds ratio 0.31, 95% Cl 0.17-0.55) and had a large combined effect on moderate-to-severe diarrhea (odds ratio 29, 95% CI 3.8-220). In 4 Lactobacillus taxa identified by 16S rRNA gene sequencing, the association between pathogen and disease was decreased, which is consistent with the possibility that Lactobacillus spp. are protective against Shigella spp. induced diarrhea. Bacterial diversity of gut microbiota was associated with diarrhea status, not high levels of the Shigella spp. ipaH gene.
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