Journal
IEEE SENSORS JOURNAL
Volume 18, Issue 12, Pages 4869-4878Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/JSEN.2018.2831779
Keywords
Amperometric sensors; biosensors; chemical and biological sensors; conductive films; polymer films; remote sensing; thick film biosensors
Funding
- Italian MiUR funding through PON R&C PLAST_ICs-plastic electronics for smart disposable systems [PON02_00355-3416798]
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Focusing on the interplay between interface chemistry, electrochemistry, and integrated electronics, we show a novel low-cost and flexible biosensing platform for continuous glucose monitoring. The amperometric biosensing system features a planar three-electrode structure on a plastic substrate, and a wireless near-field communication-powered electronic system performing sensor analog front-end, A/D conversion, digital control, and display tasks. The working electrode is made of electropolymerized poly (3,4-ethylenedioxythiophene) film onto a polyethylene terephthalate/gold electrode followed by immobilization of cross-linked glucose oxidase by glutaraldehyde. The advantages offered by such a device, including low-cost materials and instrumentation as well as the good sensitivity of 9.24 mu A/(mM . cm(2)) are promising tools for point-of-care monitoring. It is demonstrated that the devices are good candidates for the development of advanced sensing approaches based on the investigation of the noise produced during operation (fluctuation-enhanced sensing).
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