Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 44, Issue 1, Pages 57-61Publisher
IOS PRESS
DOI: 10.3233/JAD-141590
Keywords
Alzheimer's disease; gene expression; progression; TOMM40
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Funding
- National Medical Research Council (Ministry of Health, Singapore) grant
- National Healthcare Group (NHG) Clinician-Scientist Career Scheme [CSCS/12002]
- NHG [CSCS/13001]
- Duke-NUS Graduate Medical School Faculty Funds, Ministry of Health, Ministry of Education, and Ministry of Trade, Singapore
- A*StaR
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We previously reported TOMM40 to be significantly down-regulated in whole blood of Alzheimer's disease (AD) subjects at baseline and after one-year. In this longitudinal follow-up study of TOMM40 expression up to 2 years, we performed 6-monthly assessments for the first year and 2nd year blood sampling on 27 probable AD subjects compared with age- and gender-matched controls. TOMM40 gene expression remained significantly lower in AD patients at all time-points compared to controls, supported by confirmatory RT-PCR results. Our findings of consistently lower TOMM40 expression on longitudinal 2-year sampling support its potential role as a diagnostic blood AD biomarker.
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