Journal
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
Volume 25, Issue 1, Pages -Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/JSTQE.2018.2846044
Keywords
Optical fiber sensors; biophotonics
Categories
Funding
- Universiti Putra Malaysia Graduate Research Fellowship Scheme
- Ministry of Education Malaysia's MyBrain Scholarship
- TWAS-COMSTECH Joint Research Grant [14-305 RG/ENG/AS_C]
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We report the use of a biofunctionalized tapered optical fiber based sensor with the integration of graphene oxide (GO) for the detection of Dengue virus (DENV) II E proteins. The tapered region was deposited with GO and functionalized with anti-DENV II E protein IgG antibodies to be tested with different concentrations of DENV II E proteins. The sensor obtained a detection limit of 1 pM with a sensitivity value of 12.77 nm/nM, which was better compared to previously reported studies. The sensor also showed high precision, great selectivity, and high affinity toward E protein with a dissociation constant of K-d = 1.11 x 10(-9) M-1. The proposed sensor has undoubtedly exhibited the immense potential of nanomaterial integration for future advancements of dengue diagnostics.
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