Journal
RSC ADVANCES
Volume 5, Issue 10, Pages 7370-7379Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ra13711f
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Funding
- Department of Science & Technology, Government of India, New Delhi [SR/S1/OC-60/2006]
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Sequential vinylogous Michael addition-cyclization reactions of vinyl malononitriles with isatylidene malononitrile were accomplished using L-proline derived bifunctional thiourea. Cyclohexylidine malononitrile afforded exclusively the single diastereomer with good to excellent enantioselectivity (up to 99% ee) for diverse oxindole spirocyclohexene derivatives. Tetralone derived alpha,alpha-dicyano alkene was also employed to access spirocyclic oxindole scaffolds with an excellent level of stereoselectivity (up to 99% ee).
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