Journal
REGENERATIVE BIOMATERIALS
Volume 2, Issue 1, Pages 47-57Publisher
OXFORD UNIV PRESS
DOI: 10.1093/rb/rbu016
Keywords
biomaterials; scaffolds; electrically conductive polymers; bioactive nanocomposites; bone tissue engineering; molecule-releasing scaffolds; antimicrobial coatings
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Funding
- US National Institutes of Health [NIDCR DE015384, DE017689, DE022327]
- DOD [W81XWH-12-2-0008]
- National Science Foundation of the United States [DMR-1206575]
- National Natural Science Foundation of China [21304073, 51403173]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1206575] Funding Source: National Science Foundation
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Tissue engineering scaffolds play a vital role in regenerative medicine. It not only provides a temporary 3-dimensional support during tissue repair, but also regulates the cell behavior, such as cell adhesion, proliferation and differentiation. In this review, we summarize the development and trends of functional scaffolding biomaterials including electrically conducting hydrogels and nanocomposites of hydroxyapatite (HA) and bioactive glasses (BGs) with various biodegradable polymers. Furthermore, the progress on the fabrication of biomimetic nanofibrous scaffolds from conducting polymers and composites of HA and BG via electrospinning, deposition and thermally induced phase separation is discussed. Moreover, bioactive molecules and surface properties of scaffolds are very important during tissue repair. Bioactive molecule-releasing scaffolds and antimicrobial surface coatings for biomedical implants and scaffolds are also reviewed.
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