Journal
HUMAN MOLECULAR GENETICS
Volume 27, Issue R2, Pages R99-R107Publisher
OXFORD UNIV PRESS
DOI: 10.1093/hmg/ddy187
Keywords
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Funding
- FEBS_Long Term fellowship
- NWO/VENI [863.15.015]
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The capacity of the 3D-organoid cultures to resemble a near-physiological tissue organization and to mimic - to a certain degree - organ functionality, make organoids an excellent model for applications spanning from basic developmental/stem cell research to personalized medicine. Here, we review key findings achieved through organoid technology, and we discuss applications such as disease - and tumour modelling, correction of genetic mutations and understanding gene - and cell functions. Finally, we discuss future developments in the field.
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