Journal
HUMAN IMMUNOLOGY
Volume 80, Issue 1, Pages 85-89Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.humimm.2018.05.007
Keywords
Sarcoidosis; Immunopathogenesis; Mechanism; Phenotype; MHC; HLA
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Sarcoidosis is a multisystem granulomatous disease of unknown cause. Evidence supports an integral role for interactions at the MHC binding site in the development of sarcoidosis. However, despite this evidence, there are clinical data that suggest that additional mechanisms are involved in the immunopathogenesis of this disease. This manuscript provides a brief clinical description of sarcoidosis, and a clinician's perspective of the immunopathogenesis of sarcoidosis in terms of the MHC binding site, MHC functional elements beyond the binding site, and other possible alternative mechanisms. Input from clinicians will be essential in establishing the immunologic cause of sarcoidosis as a detailed phenotypic characterization of disease will be required.
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