Journal
BIO-ALGORITHMS AND MED-SYSTEMS
Volume 11, Issue 1, Pages 9-17Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/bams-2015-0001
Keywords
amyloids; Congo red; dye/metal nanoparticles; silver ion complexation; Titan yellow
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Funding
- project Interdisciplinary PhD Studies Molecular Sciences for Medicine (European Social Fund within the Human Capital Operational Programme)
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Congo red (CR) and other self-assembling compounds creating supramolecular structures of rod- or ribbon-like architecture form specific complexes with cellulose and also with many proteins, including antibodies bound to the antigen and amyloids in particular. The mechanism of complexation and structure of these complexes are still poorly recognized despite the importance of the problem for medicine. This work proposes the progress in electron microscopy studies of amyloid-dye complexes by labeling supramolecular ligand CR with silver ions as a marker. Silver ions are introduced to CR carried by the strongly binding silver dye Titan yellow, which in addition form comicellar structures with CR. Silver carried by self-assembled dye molecules forms in the resulting metal nanoparticles, making the specific amyloid ligand CR perceptible in EM studies.
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