Journal
HETEROCYCLES
Volume 96, Issue 4, Pages 707-715Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.3987/COM-18-13878
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Funding
- National Natural Science Foundation of China [21576194]
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A novel heptamethine cyanine-based turn-on fluorescent probe Cy-DNBS was designed and synthesized, which was used successfully to detect biothiols with high selectivity and sensitivity. With the addition of biothiols, the probe displayed similar to 30-fold fluorescence enhancement at 625 nm. Meanwhile, the solution color changed remarkably from green to red, which provides a method to recognize biothiols by the 'naked eye'. The detection limit of Cys, GSH and Hcy are 2.24 nM, 1.99 nM and 4.46 nM, respectively.
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