Journal
HEARING RESEARCH
Volume 360, Issue -, Pages 40-54Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.heares.2017.12.016
Keywords
Auditory model; Synapse; Neurotransmitter vesicle release; Spike timing statistics; Refractoriness; Renewal process
Funding
- NSERC Discovery Grant [261736]
- Atlantic Canada Opportunities Agency (ACOA) Innovative Communities Fund Project [204210]
- Atlantic Canada Opportunities Agency (ACOA) Business Development Program Project [205595]
- Excite Corporation
- Government of Newfoundland and Labrador Regional Development Fund [30-11044-003]
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Peterson and Heil [Hear. Res., In Press] have argued that the statistics of spontaneous spiking in auditory nerve fibers (ANFs) can be best explained by a model with a limited number of synaptic vesicle docking (release) sites (similar to 4) and a relatively-long average redocking time (similar to 16-17 ms) for each of the sites. In this paper we demonstrate how their model can be: i) generalized to also describe sound-driven ANF responses and ii) incorporated into a well-established and widely-used model of the entire auditory periphery [Zilany et al., J. Acoust. Soc. Am. 135, 283-286, 2014]. The responses of the new model exhibit substantial improvement in several measures of ANF spiking statistics, and predicted physiological forward-masking and rate-level functions from the new model structure are shown to also better match published physiological data. (C) 2017 Elsevier B.V. All rights reserved.
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