Journal
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
Volume 40, Issue 10, Pages 2295-2303Publisher
WILEY
DOI: 10.1002/hed.25209
Keywords
advanced disease; esthesioneuroblastoma; metastatic; meta-analysis; olfactory neuroblastoma
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Background The purpose of this study was to determine the clinical outcomes and review the management strategies for metastatic esthesioneuroblastoma. MethodsResultsWe conducted a systematic review and meta-analysis. Forty-eight studies totaling 118 patients met inclusion criteria. Chemotherapy in combination with surgery and/or radiation exhibited the best overall survival when compared to monotherapy and no treatment (P < .001). However, most patients (66%) received either monotherapy or no therapy. The number and location of metastases among the 3 treatment groups did not significantly differ (P = .85). Treatment modality remained significantly associated with overall survival on multivariable analysis (P < .001). Platinum-based chemotherapy was most commonly utilized but did not provide a survival benefit when compared with all other regimens (P = .88). ConclusionDistant metastases with esthesioneuroblastoma portend a poor prognosis. Chemotherapy in combination with surgery and/or radiation was associated with improved overall survival. Further research into the optimal systemic therapeutic regimen for patients with distant metastases is critical.
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