Journal
GYNECOLOGIC ONCOLOGY
Volume 149, Issue 1, Pages 205-213Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygyno.2018.01.014
Keywords
Tumor-associated macrophages; Ovarian; Endometrial; Cervical; Gynecologic cancers; Microenvironment
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Funding
- Mary Lake Polan Gynecologic Oncology Endowment for Gynecologic Cancer Research, Stanford School of Medicine, Stanford University, CA
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The complex tumor microenvironment in gynecologic cancers plays a major role in modulating anti-tumor immune responses. The interaction of cancer cells with the diverse spectrum of immune effector cells has an important impact on the efficacy of standard chemotherapy and novel immunotherapy approaches. In this review, we specifically focus on the role of macrophages in ovarian, endometrial and cervical cancers. We discuss the origins of macrophages and their polarization state dictated by the microenvironment's cues. Within the tumor niche, tumor-associated macrophages (TAMs) promote tumor growth and mediate immune-suppression thereby effecting treatment responses. We outline clinical strategies that directly target TAMs, including inhibition of macrophage differentiation, prevention of the recruitment of monocytes to the tumor, enhancement of phagocytosis and immune checkpoint blockade. (C) 2018 Elsevier Inc. All rights reserved.
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