Journal
GREEN CHEMISTRY
Volume 20, Issue 1, Pages 136-140Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7gc03177g
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The esterification of 2-phenylpropionic acid was investigated as a model system for enzyme catalysed (CALB, Novozyme 435) reactions in bio-based solvents. A multi-parameter correlation taking into account solvent parameters was developed to explain experimental observations. A continuous flow process using p-cymene as the solvent was operated over several weeks, thus combining a sustainable solvent and flow chemistry for kinetic resolution.
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