Journal
GREEN CHEMISTRY
Volume 20, Issue 12, Pages 2775-2780Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8gc00987b
Keywords
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Funding
- National Natural Science Foundation of China [81673296]
- Tianjin University of Science Technology
- Region Alsace
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An efficient synthesis of fully substituted 2,3-dihydropyrroles has been achieved in one step through the three-component reaction of amines, aromatic aldehydes and a-ketoamides. This atom-economical and catalyst-free reaction is highly stereoselective and generates underexplored heterocycles in a single step. These compounds were examined in an enzymatic assay that led to the identification of potent a-glucosidase inhibitors, thereby demonstrating the utility of this novel methodology in medicinal chemistry.
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