Journal
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
Volume 3, Issue 2, Pages 99-108Publisher
XIA & HE PUBLISHING INC
DOI: 10.14218/JCTH.2015.00007
Keywords
DILI; Hepatotoxicity; Treatment
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Drug-induced liver injury (DILI) is a rare but potentially life threatening adverse drug reaction. DILI may mimic any morphologic characteristic of acute or chronic liver disease, and the histopathologic features of DILI may be indistinguishable from those of other causes of liver injury, such as acute viral hepatitis. In this review article, we provide an update on causative agents, clinical features, pathogenesis, diagnosis modalities, and outcomes of DILI. In addition, we review results of recently reported genetic studies and updates on pharmacological and invasive treatments. (C) 2015 The Second Affiliated Hospital of Chongqing Medical University. Published by XIA & HE Publishing Ltd. All rights reserved.
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