Journal
EUROPEAN JOURNAL OF DERMATOLOGY
Volume 25, Issue -, Pages 33-42Publisher
JOHN LIBBEY EUROTEXT LTD
DOI: 10.1684/ejd.2015.2553
Keywords
extracellular matrix; matrix metalloproteinases; keratinocyte; migration; skin; wound healing
Categories
Funding
- Agence Nationale pour la Recherche [ANR-13-RPIB-0003-01]
- Ligue Nationale contre le Cancer
- ARC2 program of the Region Rhone-Alpes
Ask authors/readers for more resources
Epithelialization of normal wounds occurs by an orderly series of events whereby keratinocytes migrate, proliferate, and differentiate to restore the epidermal bather function. Keratinocyte migration is one of the earliest and crucial events determining the efficiency of the overall wound repair process. In response to various stimuli including that of growth factors, cytokines and the extracellular matrix, activated keratinocytes at the edges of the wound undergo dramatic morphological changes according to their migratory behaviour through development of protrusive adhesion contacts and cytoskeleton rearrangements. These phenotypic changes are accompanied by the upregulated expression of a new set of genes, among which are adhesion receptors and specific matrix degrading enzymes named matrix metalloproteinases (MMPs). The tightly regulated spatial and temporal MMP expression is crucial for proper re-epithelialization. These multi-domain zinc-containing endopeptidases are necessary for the proper completion of multiple features of epidermal regeneration. They play a key role in the migration process by controlling the repeated cycles of keratinocyte attachment and retraction. In the meantime, they process, degrade or remodel the extracellular matrix often producing cleavages in a gain-of-function manner.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available