Journal
NATURE REVIEWS CANCER
Volume 15, Issue 4, Pages 248-254Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3896
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Funding
- US National Institutes of Health/National Cancer Institute (NIH/NCI) [R01CA155664, R01CA158668, R01CA170851, CA155664-03S1]
- Susan G. Komen Breast Promise Award [KG091020]
- V-Foundation Award
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Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype that disproportionately affects BRCA1 mutation carriers and young women of African origin. There is evidence that African-American women with TNBC have worse clinical outcomes than women of European descent. However, it is unclear whether survival differences persist after adjusting for disparities in access to health-care treatment, co-morbid disease and income. It remains controversial whether TNBC in African-American women is a molecularly distinct disease or whether African-American women have a higher incidence of aggressive biology driven by disparities: there is evidence in support of both. Understanding the relative contributions of biology and disparities is essential for improving the poor survival rate of African-American women with TNBC.
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