Journal
GENES & DEVELOPMENT
Volume 32, Issue 13-14, Pages 865-867Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.316943.118
Keywords
POU2F3; small cell lung cancer; tuft cell; master regulator; enhancer
Categories
Funding
- National Cancer Institute Specialized Programs of Research Excellence (SPORE) in Lung Cancer [P50CA70907, UO1CA213338]
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Tumor heterogeneity of a primary histologic cancer type has major implications for cancer research and therapeutics. An important and understudied aspect of this heterogeneity is the role of transcription factors that serve as lineage oncogenes in a tumor type. A demonstration that different subgroups have distinct dependencies on lineage-specific transcription factors is highlighted in a relatively homogenous cancer type: the pulmonary neuroendocrine cancer small cell lung carcinoma (SCLC). Identification of these factors is providing new insights into the origin of the heterogeneity and subtype-specific vulnerabilities in SCLC and provides a template for studying heterogeneity in other cancer types.
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