Journal
GENES & DEVELOPMENT
Volume 32, Issue 7-8, Pages 463-465Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.315168.118
Keywords
acetyl-CoA; histone acetylation; metabolism; calcium; NFAT1; glioblastoma
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Funding
- [5R35CA197532-02]
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Fluctuations in acetyl-coenzyme A (acetyl-CoA) levels have been previously associated with changes in global histone acetylation and gene expression. The study by Lee and colleagues (pp. 497-511) in this issue of Genes & Development demonstrates that acetyl-CoA can promote the up-regulation of cell migration-and adhesion-related genes in glioblastoma by controlling Ca2+-NFAT (nuclear factor of activated T cells) signaling.
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