Journal
GENERAL AND COMPARATIVE ENDOCRINOLOGY
Volume 267, Issue -, Pages 137-145Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygcen.2018.06.015
Keywords
Peptide YY (PYY); Hypothalamus; Hindbrain; Fatty acid sensing; Rainbow trout
Categories
Funding
- Natural Sciences and Engineering Research Council (NSERC) of Canada
- Saskatchewan Health Research Foundation (SHRF)
- John R. Evans Leaders Fund from the Canada Foundation for Innovation
- Spanish Agenda Estatal de Investigacion (AEI)
- European Fund of Regional Development [AGL2016-74857-C3-1-R]
- European Fund of Regional Development (FEDER)
- Universidade de Vigo
- Xunta de Galicia
Ask authors/readers for more resources
We hypothesized that peptide YY (PYY) is involved in the metabolic regulation of food intake in fish. Therefore, we assessed in rainbow trout (Oncorhynchus mykiss) the effects of intracerebroventricular treatment with 10 ng/g PYY1-36 on food intake, expression of neuropeptides involved in food intake control, and the activity of fatty acid-sensing systems. The administration of PYY1-36 caused a significant reduction in food intake up to 24 h post-treatment. This anorectic action was associated with changes 2 h after treatment in mRNA abundance of neuropeptides involved in metabolic regulation of food intake in hypothalamus (decreased NPY and raised CART values) and hindbrain (increased POMCa1 values). We also observed that PYY1-36 treatment induced changes in mRNA abundance of parameters related to fatty acid sensing and metabolism in hypothalamus (decreased values of ACLY, PPAR gamma, and SREBP1c) and hindbrain (increased values of LPL, FAT/CD36, PPAR alpha, PPAR gamma, and SREBP1c and decreased values of UCP2a). PYY1-36 treatment also increased mRNA abundance of mTOR. In general, it seems that mRNAs encoding some components of the machinery required for fatty acid sensing and metabolism are activated by PYY1-36. The response observed was higher in the hindbrain than in the hypothalamus, supporting the greater importance of this brain area in mediating the modulatory effects of gastrointestinal hormones on feeding regulation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available