4.7 Article

Novel Mutations in K13 Propeller Gene of Artemisinin-Resistant Plasmodium falciparum

Journal

EMERGING INFECTIOUS DISEASES
Volume 21, Issue 3, Pages 490-492

Publisher

CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid2103.140898

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Funding

  1. Institute of Tropical Medicine [2013-A-7, 2014-A-18]
  2. Japan Society for Promotion of Science [24390141, 26257504]
  3. Health Labour Science Research Grant
  4. Japanese Society for the Promotion of Science Core-to-Core Program B, Asia-Africa Science Platforms
  5. Grants-in-Aid for Scientific Research [26257504, 24390141] Funding Source: KAKEN

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We looked for mutations in the Plasmodium falciparum K13 propeller gene of an artemisinin-resistant parasite on islands in Lake Victoria, Kenya, where transmission in 2012-2013 was high. The 4 new types of nonsynonymous, and 5 of synonymous, mutations we detected among 539 samples analyzed provide clues to understanding artemisinin-resistant parasites.

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