Journal
GENE
Volume 674, Issue -, Pages 115-120Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gene.2018.06.049
Keywords
EMT; Metastasis; miRNA; TF
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Epithelial to mesenchymal transition (EMT) is a phenomenon in which epithelial cells lose their cell to cell adhesion and detach from the base of the membrane. EMT is a fundamental process which occurs during tumor progression and metastasis. Cancer genomics is a complex network which involves a variety of factors such as transcription factors (TFs), coding genes and microRNAs (miRs). Both TFs and miRs are trans-regulatory elements that crosstalk. Due to a wide range of targets, TF-miR interaction provides a feedback or feedforward loop and cross-gene regulation consequently. In this review, we focused on the structure and function of two TF families involved in EMT, zinc finger and beta helix loop helix and p53. Subsequently we analyzed recent findings on TF-miR interaction in EMT.
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