Journal
GENE
Volume 651, Issue -, Pages 174-182Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gene.2018.02.013
Keywords
mRNA; Translation initiation; uORF; TISU; IRES; Protein synthesis; Autoregulation; eIF
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Funding
- Russian Science foundation [16-14-10065]
- Russian Science Foundation [16-14-10065] Funding Source: Russian Science Foundation
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Eukaryotic cells evolved highly complex and accurate protein synthesis machinery that is finely tuned by various signaling pathways. Dysregulation of translation is a hallmark of many diseases, including cancer, and thus pharmacological approaches to modulate translation become very promising. While there has been much progress in our understanding of mammalian mRNA-specific translation control, surprisingly, relatively little is known about whether and how the protein components of the translation machinery shape translation of their own mRNAs. Here we analyze mammalian mRNAs encoding components of the translation initiation machinery for potential regulatory features such as 5'TOP motifs, TISU motifs, poor start codon nucleotide context and upstream open reading frames.
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