Journal
RSC ADVANCES
Volume 5, Issue 29, Pages 22365-22372Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ra00701a
Keywords
-
Categories
Funding
- Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning, National Natural Science Foundation of China [51102166]
- Program for New Century Excellent Talent in University [NCET-12-1053]
- Shanghai Shuguang Project [12SG39]
- Key Project of Chinese Ministry of Education [212055]
- Hujiang Foundation of China [B14006]
Ask authors/readers for more resources
We proposed a strategy to construct DNA-capped Fe3O4/SiO2 magnetic mesoporous silica (MMS) nanoparticles for potential temperature controlled drug release and magnetic hyperthermia. Drug release behavior, magnetic heating capacity, in vitro cytotoxicity, and cell uptake of the MMS-based nanocarriers were evaluated. The results showed that the DOX/MMS-NH2-dsDNA complexes could release DOX fast at 50 degrees C, but very slow at 37 degrees C. Also, MMS-based nanocarriers could efficiently generate heat upon exposure to an alternating magnetic field due to the superparamagnetic behavior. Furthermore, the MMS-NH2-dsDNA complexes could be effectively taken up by murine breast cancer 4T1 cells, and negligible cytotoxicity of the MMS-NH2-dsDNA complexes has been observed. Therefore, DNA-capped MMS nanoparticles had potential for cancer therapy with temperature controlled drug release and magnetic hyperthermia.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available