4.7 Article

Pathogenicity of 2 Porcine Deltacoronavirus Strains in Gnotobiotic Pigs

Journal

EMERGING INFECTIOUS DISEASES
Volume 21, Issue 4, Pages 650-654

Publisher

CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid2104.141859

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Funding

  1. Four Star Animal Health Inc. (Loramie, OH, USA)
  2. Ohio Agricultural Research and Development Center SEEDS Program [OAOH1536]

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To verify whether porcine deltacoronavirus infection induces disease, we inoculated gnotobiotic pigs with 2 virus strains (OH-FD22 and OH-FD100) identified by 2 specific reverse transcription PCRs. At 21-120 h postinoculation, pigs exhibited severe diarrhea, vomiting, fecal shedding of virus, and severe atrophic enteritis. These findings confirm that these 2 strains are enteropathogenic in pigs.

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